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醫(yī)藥研發(fā)求職簡(jiǎn)歷模板使用便捷-高效-實(shí)用，高效提升求職效率，做高質(zhì)量簡(jiǎn)歷就用錘子簡(jiǎn)歷。

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? 頭像: 隱藏

編輯

["sex","age","nation","education","marriageStatus","politicalStatus","city","jobYear","mobile","email"]

? 基本信息: 女

26歲



本科





?

3年經(jīng)驗(yàn)

13800138000

BD@100chui.com

 技能特長(zhǎng): 執(zhí)行能力精通

溝通能力精通

學(xué)習(xí)能力精通

+

? 姓名: 錘子簡(jiǎn)歷

世界屬于那些勤于思考的人，更屬于那些善于行動(dòng)的人。

 求職意向: 
醫(yī)藥研發(fā)


廣州


面議


隨時(shí)到崗

 教育背景: 2014年9月 - 2018年6月

錘子簡(jiǎn)歷大學(xué)

計(jì)算機(jī)與信息技術(shù)

GPA：3.72/4
GRE：324

 工作經(jīng)驗(yàn)

2019.03 - 至今

錘子簡(jiǎn)歷信息有限公司

醫(yī)藥研發(fā)

負(fù)責(zé)從PBMC中分選T細(xì)胞和Monocyte，并將Monocyte刺激分化巨噬細(xì)胞和樹(shù)突狀細(xì)胞。
負(fù)責(zé)進(jìn)行ADCP實(shí)驗(yàn)，利用FACS檢測(cè)抗體依賴(lài)的巨噬細(xì)胞吞噬效應(yīng)。負(fù)責(zé)實(shí)驗(yàn)計(jì)劃和實(shí)驗(yàn)結(jié)果分析總結(jié)。負(fù)責(zé)工具細(xì)胞株構(gòu)建。
負(fù)責(zé)TAM的免疫抑制信號(hào)通路如SIRPa- -CD47，Siglec10- -CD24，PD1- -PDL1等的專(zhuān)利和文獻(xiàn)調(diào)研。

2018.03 - 2019.03

錘子簡(jiǎn)歷科技有限公司

醫(yī)藥研發(fā)

雜交瘤抗體細(xì)胞庫(kù)的建立和鑒定，雜交瘤抗體陽(yáng)性細(xì)胞株表面受體量的表達(dá)檢測(cè)及定量;
Fortebio、ELISA實(shí)驗(yàn)體系的開(kāi)發(fā)，驗(yàn)證，以及與CRO公司方法的轉(zhuǎn)移;
2"ADC細(xì)胞殺傷性實(shí)驗(yàn)體系的開(kāi)發(fā)及驗(yàn)證，以及陽(yáng)性抗體的篩選;
雜交瘤陽(yáng)性高表達(dá)細(xì)胞株的篩選，培養(yǎng)，上清收集及凍存；陽(yáng)性抗體親和力的測(cè)定-ELISA: EC50和Fortebio: KD;
雜交瘤陽(yáng)性抗體提取CDR區(qū)域，以及人源化；嵌合抗體和人源化的抗體理化性質(zhì)的鑒定和分析;
抗體Epitobe競(jìng)爭(zhēng)實(shí)驗(yàn)方法的開(kāi)發(fā)方法；抗體功能學(xué)實(shí)驗(yàn)的開(kāi)發(fā)及實(shí)驗(yàn)步驟的確定; ADCC, CDC，細(xì)胞的凋亡和周期，細(xì)胞的內(nèi)吞實(shí)驗(yàn)等等;

 項(xiàng)目經(jīng)驗(yàn)

2021.03 - 2021.06

項(xiàng)目工程

醫(yī)藥研發(fā)

項(xiàng)目描述：從近200個(gè)靶向BCR- -ABL的PROTAC小分子中，篩選到了多個(gè)能夠降解BCR- -ABL蛋白的小分子,其在靶標(biāo)，細(xì)胞水平均表現(xiàn)出很好的生物學(xué)活性和選擇性。本人參與完成了蛋白降解靶向BCR-ABL化合物及其抗腫瘤應(yīng)用的專(zhuān)利撰寫(xiě)和專(zhuān)利申請(qǐng)。最后從降解效果較好的化合物中選取了一個(gè)先導(dǎo)化合物進(jìn)行了動(dòng)物實(shí)驗(yàn)藥效學(xué)和作用機(jī)制方面研究。
責(zé)任描述：蛋白質(zhì)免疫印跡Western-blot測(cè)定PROTAC蛋白降解化合物對(duì)慢性粒細(xì)胞白血病細(xì)胞降解效果測(cè)定;
利用定點(diǎn)突變技術(shù)，構(gòu)建臨床耐藥細(xì)胞株，并利用真核轉(zhuǎn)染技術(shù)體外表達(dá)后流式細(xì)胞術(shù)分選耐藥細(xì)胞株;
利用免疫共沉淀技術(shù)研究蛋白的相互作用;利用蛋白質(zhì)組學(xué)研究了PROTAC藥物其他蛋白的降解效果影響的研究，利用激酶組學(xué)測(cè)定了PROTAC藥物對(duì)激酶的影響;也測(cè)定了先導(dǎo)化合物的藥物的透膜性;
利用CDX動(dòng)物模型在NOD- -SCID人源化小鼠中對(duì)先導(dǎo)化合物進(jìn)行抗白血病的體內(nèi)效果研究;

 自我評(píng)價(jià): 本人對(duì)待工作踏實(shí)，認(rèn)真，并且極富工作和團(tuán)隊(duì)精神，因此在工作和生活中結(jié)交了許多朋友，具有良好的適應(yīng)性和熟練的溝通技巧，相信能夠協(xié)助主管人員出色地完成各項(xiàng)工作。忠誠(chéng)穩(wěn)重堅(jiān)守誠(chéng)信正直原則，勇于挑戰(zhàn)自我開(kāi)發(fā)自身潛力。感謝您在百忙之中閱覽我的簡(jiǎn)歷，靜候佳音！